PAC633 - Organic Chemistry

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Last revision date Jan 14, 2021 3:40:26 PM
Last review date Jan 14, 2021 3:40:26 PM

Subject Title
Organic Chemistry

Subject Description
This subject offers both lecture and laboratory components. This course will cover topics relevant to the pharmaceutical industry with an emphasis on the organic chemistry concepts behind the topics. This lecture portion of the course will cover the structural and pharmaceutical properties of amines and amides, theory and interpretation of Mass Spectra, practical aspects of liquid and gas chromatography (HPLC, LCMS and GCMS) and a special topic of current interest in the pharmaceutical industry. The laboratory portion of the course features a mutli-step synthesis of the topical anaesthetic Lidociane, analysis of Lidocaine by HPLC using a USP protocol and qualitative analysis of an unknown mixture of comppunds by GCMS.

Credit Status
Worth one credit towards Chemical Laboratory Technology - Pharmaceutical program, Semester 6

Learning Outcomes
Upon successful completion of this subject the student will be able to:

Upon the successful completion of this course, the student will be able to:

  • Perform a nucleophilic acylation reaction.
  • Explain the reactivity differences of various carboxylic acids in the acylation reaction.
  • Explain the reactivity differences of various amines as nucleophiles.
  • Calculate percent loss, percent yield and overall yield in organic synthesis.
  • Explain the basic instrumentation in a mass spectrometer coupled with a gas chromatographic system.
  • Explain the basic theory of an electron ionization mass spectrometer and detection by a quadrupole mass analyzer.
  • Perform a qualitative analysis of an organic mixture in a mass spectrometer coupled with a gas chromatographic system.
  • Explain the meaning of SCAN mode in mass spectral analysis.
  • Explain the meaning of a total ion chromatogram in mass spectral analysis.
  • Generate a total ion chromatogram from mass spectral data.
  • Perform qualitative identification of a molecule by library search in mass spectral analysis.
  • Explain the meaning of and the use of an extracted ion chromatogram in mass spectral analysis.
  • Generate an extracted ion chromatogram in mass spectral analysis.
  • Check the validity of a library identification by isotopic abundance ratio.
  • Explain the basic principles of an electron spray ionization mass spectrometry.
  • Operate Hewlett Packard liquid chromatograph with Agilent 1200 software, Agilent 7890, gas chromatograph with single quadrupole MSD
  • Execute a USP protocol in the analysis of an organic chemical.
  • Know the basic theory of GC-MS ( EID) and LC-MS ( Electrospray).
  • Perform accurate analytical preparations.
  • Record and report scientific data following the principles of Good Laboratory Practice.
  • Locate and adhere to accepted safety practices while performing laboratory work (WHMIS, MSDS).

Essential Employability Skills

    •  Communicate clearly, concisely and correctly in the written, spoken and visual form that fulfils the purpose and meets the needs of the audience.

    •  Respond to written, spoken, or visual messages in a manner that ensures effective communication.

    •  Execute mathematical operations accurately.

    •  Apply a systematic approach to solve problems.

    •  Use a variety of thinking skills to anticipate and solve problems.

    •  Locate, select, organize, and document information using appropriate technology and information systems.

    •  Analyze, evaluate, and apply relevant information from a variety of sources.

Academic Integrity
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Please visit the Academic Integrity website to understand and learn more about how to prepare and submit work so that it supports academic integrity, and to avoid academic misconduct.

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Accommodation for Students with Disabilities
The College will provide reasonable accommodation to students with disabilities in order to promote academic success. If you require accommodation, contact the Counselling and Accessibility Services Office at ext. 22900 to initiate the process for documenting, assessing and implementing your individual accommodation needs.