PAC633 - Organic Chemistry

Outline information
Semester
Schools offering this subject
Last revision date 2023-10-02 00:55:30.485
Last review date 2023-12-04 00:15:12.54

Subject Title
Organic Chemistry

Subject Description
This subject offers both lecture and laboratory components. This course will cover topics relevant to the pharmaceutical industry with an emphasis on the organic chemistry concepts behind the topics. This lecture portion of the course will cover the structural and pharmaceutical properties of amines and amides, theory and interpretation of Mass Spectra, practical aspects of liquid and gas chromatography (HPLC, LCMS and GCMS) and a special topic of current interest in the pharmaceutical industry. The laboratory portion of the course features a mutli-step synthesis of the topical anaesthetic Lidociane, analysis of Lidocaine by HPLC using a USP protocol and qualitative analysis of an unknown mixture of comppunds by GCMS.

Credit Status
Worth one credit towards Chemical Laboratory Technology - Pharmaceutical program, Semester 6

Learning Outcomes
Upon successful completion of this subject the student will be able to:

Upon the successful completion of this course, the student will be able to:
 

  • Perform a nucleophilic acylation reaction.
  • Explain the reactivity differences of various carboxylic acids in the acylation reaction.
  • Explain the reactivity differences of various amines as nucleophiles.
  • Calculate percent loss, percent yield and overall yield in organic synthesis.
  • Explain the basic instrumentation in a mass spectrometer coupled with a gas chromatographic system.
  • Explain the basic theory of an electron ionization mass spectrometer and detection by a quadrupole mass analyzer.
  • Perform a qualitative analysis of an organic mixture in a mass spectrometer coupled with a gas chromatographic system.
  • Explain the meaning of SCAN mode in mass spectral analysis.
  • Explain the meaning of a total ion chromatogram in mass spectral analysis.
  • Generate a total ion chromatogram from mass spectral data.
  • Perform qualitative identification of a molecule by library search in mass spectral analysis.
  • Explain the meaning of and the use of an extracted ion chromatogram in mass spectral analysis.
  • Generate an extracted ion chromatogram in mass spectral analysis.
  • Check the validity of a library identification by isotopic abundance ratio.
  • Explain the basic principles of an electron spray ionization mass spectrometry.
  • Operate Hewlett Packard liquid chromatograph with Agilent 1200 software, Agilent 7890, gas chromatograph with single quadrupole MSD
  • Execute a USP protocol in the analysis of an organic chemical.
  • Know the basic theory of GC-MS ( EID) and LC-MS ( Electrospray).
  • Perform accurate analytical preparations.
  • Record and report scientific data following the principles of Good Laboratory Practice.
  • Locate and adhere to accepted safety practices while performing laboratory work (WHMIS, MSDS).

Essential Employability Skills

    •  Communicate clearly, concisely and correctly in the written, spoken and visual form that fulfils the purpose and meets the needs of the audience.

    •  Respond to written, spoken, or visual messages in a manner that ensures effective communication.

    •  Execute mathematical operations accurately.

    •  Apply a systematic approach to solve problems.

    •  Use a variety of thinking skills to anticipate and solve problems.

    •  Locate, select, organize, and document information using appropriate technology and information systems.

    •  Analyze, evaluate, and apply relevant information from a variety of sources.

Academic Integrity
Seneca upholds a learning community that values academic integrity, honesty, fairness, trust, respect, responsibility and courage. These values enhance Seneca's commitment to deliver high-quality education and teaching excellence, while supporting a positive learning environment. Ensure that you are aware of Seneca's Academic Integrity Policy which can be found at: http://www.senecapolytechnic.ca/about/policies/academic-integrity-policy.html Review section 2 of the policy for details regarding approaches to supporting integrity. Section 2.3 and Appendix B of the policy describe various sanctions that can be applied, if there is suspected academic misconduct (e.g., contract cheating, cheating, falsification, impersonation or plagiarism).

Please visit the Academic Integrity website http://open2.senecac.on.ca/sites/academic-integrity/for-students to understand and learn more about how to prepare and submit work so that it supports academic integrity, and to avoid academic misconduct.

Discrimination/Harassment
All students and employees have the right to study and work in an environment that is free from discrimination and/or harassment. Language or activities that defeat this objective violate the College Policy on Discrimination/Harassment and shall not be tolerated. Information and assistance are available from the Student Conduct Office at student.conduct@senecapolytechnic.ca.

Accommodation for Students with Disabilities
The College will provide reasonable accommodation to students with disabilities in order to promote academic success. If you require accommodation, contact the Counselling and Accessibility Services Office at ext. 22900 to initiate the process for documenting, assessing and implementing your individual accommodation needs.

Camera Use and Recordings - Synchronous (Live) Classes
Synchronous (live) classes may be delivered in person, in a Flexible Learning space, or online through a Seneca web conferencing platform such as MS Teams or Zoom. Flexible Learning spaces are equipped with cameras, microphones, monitors and speakers that capture and stream instructor and student interactions, providing an in-person experience for students choosing to study online.

Students joining a live class online may be required to have a working camera in order to participate, or for certain activities (e.g. group work, assessments), and high-speed broadband access (e.g. Cable, DSL) is highly recommended. In the event students encounter circumstances that impact their ability to join the platform with their camera on, they should reach out to the professor to discuss. Live classes may be recorded and made available to students to support access to course content and promote student learning and success.

By attending live classes, students are consenting to the collection and use of their personal information for the purposes of administering the class and associated coursework. To learn more about Seneca's privacy practices, visit Privacy Notice.